Wilshere, 23, has made 16 appearances this season in a campaign that has been blighted by injuries.
In his place in central midfield, Cazorla, Aaron Ramsey and Francis Coquelin have all shone at various stages of the campaign.
But when discussing his ideal midfield partner, Wilshere reserved special praise for Spaniard Cazorla, who has hit real form in recent weeks.
The 30-year-old was instrument in Arsenal’s 4-1 win over Liverpool last weekend - his 47th appearance for club and country this season - and Wilshere revealed why Cazorla is so influential on the pitch.
“With Santi it’s easy to play because he understands the game so well,” Wilshere told arsenal.com.
“If I come inside, he’ll go outside and we’ll link up. Now he’s got more responsibility in the centre of midfield and he’s done brilliantly there over the last few months.
“He’s probably the easiest player to play with.”
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Santi Cazorla (left) and Aaron Ramsey have both impressed at Arsenal this spring
And when discussing Ramsey’s impactful return to the squad from injury, Wilshere compared the Wales international to former England stars Steven Gerrard and Frank Lampard.
“[Aaron’s] main attribute is his energy, his leadership, he wants to drive the team forward and he can score goals,” Wilshere added.
“You look at the best midfielders in the world over the last few years like Lampard and Gerrard, who can score goals, and he’s got that.”
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