United were hoping to restore the 19-year-old left-back to the match day squad for the game against Liverpool today (1.30pm).
Louis van Gaal was thought to be hoping to have Shaw on the bench.
But he won't be involved after being omitted from the squad.
GETTY
Luke Shaw has pulled out of the England squad
Shaw pulled out of England's squad for the upcoming Euro 2016 qualifier against Lithuania next Friday and their international friendly against Italy the following Wednesday.
Instead, Tottenham left-back Danny Rose has been drafted in.
United will deploy Daley Blind at left-back instead for the must-win clash at Anfield.
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