And, with that showdown in mind, Pochettino is set to ring the changes when relegated Huddersfield come to town.
Harry Kane is a certainty to miss out against the Terriers due to the severe ankle injury he suffered during the week.
And it is anticipated Son will replace him through the middle as Tottenham’s main striking threat.
Pochettino hailed the South Korean yesterday, claiming he should be in the running for the Premier League Player of the Year award.
Tottenham team news: Predicted 5-3-2 to face Huddersfield - Kane replacement, 7 changes (Image: GETTY)
“If we assess after November, he can be a contender,” Pochettino said. “But the first few months of the competition, I think no. He has travelled a little bit because he was in the Asian Cup, but after November he has been fantastic.
“We are not going to put an excuse if we in the end don't achieve. But the reality is missing one of your best players, of course, that is not an advantage. It's a big disadvantage. But how we are, we don't like to find excuses.
“We are going to try to make our job. And of course there are different players we have in front, they need to step up and of course they are going to make the job like we need to be sure to be in the top four or to compete against Manchester City next Wednesday.”
Pochettino is expect to bring in Lucas Moura and pair the winger with Son as he reverts to a 5-3-2 system at the Tottenham Hotspur Stadium.
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Tottenham team news: Predicted 5-3-2 to face Huddersfield - Kane replacement, 7 changes (Image: GETTY)
Christian Eriksen will retain his place for Spurs, but play slightly further forward than against City.
Victor Wanyama and Oliver Skipp are poised to come in at the base of midfield for Moussa Sissoko and Harry Winks respectively.
Pochettino is set to include four different faces in defence as he goes with a back five against Huddersfield.
Kyle Walker-Peters and Ben Davies will replace Kieran Trippier and Danny Rose on the flanks.
Tottenham team news: Predicted 5-3-2 to face Huddersfield - Kane replacement, 7 changes (Image: GETTY)
Tottenham team news: Predicted 5-3-2 to face Huddersfield - Kane replacement, 7 changes (Image: BUILDLINEUP.COM)
While Jan Vertonghen will be the only central defender who featured in midweek to take on City, with Juan Foyth and Davinson Sanchez slotting in alongside him.
Tottenham No 1 Hugo Lloris will continue in goal as Pochettino’s side seek to replicate the 2-0 win they secured over Huddersfield in September.
Tottenham are fourth as they prepare to welcome Jan Siewert’s squad to north London today.
And they will be desperate to get the three points which would see them leapfrog Chelsea into third.
Predicted 5-3-2 Tottenham line up: Lloris; Walker-Peters, Foyth, Sanchez, Vertonghen, Davies; Skipp, Wanyama, Eriksen; Moura, Son